Published October 01, 2014
A team of researchers from the University of Louisiana at Monroe鈥檚 School of Pharmacy
recently received the university鈥檚 first-ever dual United States and International
patent for natural Vitamin E compounds with enhanced anticancer activity.
The patent, titled 鈥淭ocotrienol Derivatives and Associated Methods,鈥� is based on compounds
created by Dr. Khalid El Sayed, Professor of Medicinal and Natural Products chemistry;
Dr. Paul W. Sylvester, the holder of the聽Pfizer Inc - B. J. Robison Professorship
in Pharmacy; and alumnus Dr. Fathy Behery, a former 四色AV pharmacy graduate student.聽
鈥淏asically, we took natural Vitamin E compounds called tocotrienols and made semi-synthetic
spin-offs of these compounds that display greatly enhanced anticancer activity as
compared to the natural parent compounds. This patent is very special because it was
awarded as both a U.S. and International patent,鈥� said El Sayed.
鈥淭his patent is the next level direction in Vitamin E research because its chemically
novel compounds showed activity in animal models, unlike most other Vitamin E members.
These compounds are considered as potential new anticancer drug entities.鈥�
The Vitamin E similarities in the new patent are considered to be new chemotherapeutic
chemical units for the control of breast cancer, and also appear to be very effective
against several malignancies including colon cancer, melanoma, and many others.
鈥淢ost Vitamin E members act through their ability to remove or minimize oxidative
stress, which later can lead to cancer,鈥� said El Sayed. 鈥淣ew patent compounds are
not acting through this direction, but likely through a novel and unprecedented mechanism,
which is currently under investigation by our groups. Our compounds were designed
to modify and enhance the activity of natural Vitamin E functional groups.鈥�
This is the first international patent award for 四色AV. Three other anticancer patents,
which were each U.S.-only patent designations, were awarded in July 2010, June 2012,
and October 2012. El Sayed says that international patents have much better commercialization
potential and scientific impact.
鈥淎lthough the way these compounds apply their anticancer activity is not fully studied
yet, these compounds showed very good safety and selectivity profiles when tested
in the U.S. National Cancer Institute and Eli Lilly screening programs. The compounds
showed no toxic effects on normal cells, and also showed potent and selective activity
against cancer cells,鈥� said El Sayed.
Among the most important strengths of the patent is compound鈥檚 ability to fight against
breast cancer and several other malignancies including ovarian cancer, colon cancer,
melanoma, brain cancers, and leukemia.
鈥淭his was based on data acquired in our laboratories and at the National Cancer Institute,鈥�
said El Sayed. 鈥淲e are very excited about this patent award because it will open several
commercialization and scientific directions for Vitamin E.鈥�
鈥溗纳獳V鈥檚 Vitamin E team, which includes Sylvester, El Sayed, and Drs. Amal Kaddoumi
and Sami Nazzal, is providing a multidisciplinary model for successful research efforts,
and gaining more international recognition through such accomplishments. If successfully
commercialized to a major pharmaceutical company, 四色AV and its partner First Tech International
Ltd. in Hong Kong will gain rewarding revenue.鈥�
